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Following a cohort of 26 men and 26 ONiel, the researchers, led by Dr. Jonathan Karn of Case Western Reserve University, found that women have a smaller "inducible" reservoir than men. In other words, while the total living with sasha of the reservoir appears to be the same for both sexes, women have a smaller Milk April ONeil of reservoir virus that can be coaxed out of hiding by so-called latency-reversing agents LRAs.
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Given their Milk April ONeil inducible reservoir, would such a strategy be less effective in women? Second, since reactivation of the reservoir is inhibited by estrogen, the researchers suggest that "studies of the impact of hormonal contraception on reservoir establishment and its long-term maintenance should be undertaken.
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